Definition:

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Mineraux®Manganese gluconate Health Benefits:

Manganese is widely distributed throughout the biosphere; however, its concentration in the human body is minimal, making it an essential trace element. In the body, manganese acts partly as a component of metalloproteins and partly as an enzyme activator. Examples of manganese-containing enzymes include arginase, pyruvate carboxylase and manganese superoxide dismutase. Arginase is an enzyme found in the cytoplasm that catalyses urea synthesis. Pyruvate carboxylase catalyses the first step in the synthesis of carbohydrates from pyruvate. Manganese activates numerous enzymes, including oxidoreductases, hydrolases, ligases, kinases, decarboxylases, and transferases. Manganese deficiency can lead to various biochemical and structural defects, including growth disorders, skeletal deformities and reproductive dysfunction. Excellent sources of manganese include grains, followed by vegetables and fruits. Dairy products, meat, fish and poultry contain very little manganese. Manganese can also be obtained through dietary supplements.

Mineraux®Manganese gluconate is an organic manganese salt formed by combining manganese ions with the anion gluconate. Its core characteristics include high bioavailability, minimal gastrointestinal irritation, excellent solubility and good palatability. These properties make it an ideal raw material for fortifying food, health supplements and special dietary products with manganese. Manganese is an essential trace element for the human body that participates in critical physiological processes such as bone formation, metabolic enzyme activation, and neural development. The organic form of manganese (manganese gluconate) is more suitable for populations including children, the elderly, and individuals with gastrointestinal sensitivities than inorganic manganese salts are.

Particularities of Mineraux®Manganese gluconate:

Product Specifications:

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Product quality standards:

● USP, BP, EP, GB 1903.7, Food grade, In-house

▶Bone health

Mineraux®Manganese gluconate Applications:

Manganese is a key cofactor in bone formation. Manganese gluconate efficiently supplements manganese to strengthen bone structural stability. Manganese activates collagen synthase, promotes collagen cross-linking, and enhances bone matrix strength. It also synergizes with calcium and vitamin D to improve calcium deposition efficiency in bones, maintaining the balance between bone formation and resorption.

■ Core features

Mineraux®Manganese gluconate is an ionic organic salt, in which manganese and gluconate ions are bonded together by ionic bonds. The polyhydroxy structure of gluconate reduces binding with phytic acid and tannic acid in the intestine while preventing direct irritation of the gastrointestinal mucosa by manganese ions. This significantly enhances absorption efficiency. Manganese gluconate is highly absorbable and aligns with human metabolic processes. Its absorption rate of elemental manganese reaches approximately 35%-45% (significantly higher than the 15%-20% absorption rate of manganese sulfate), making it two to three times more effective than inorganic manganese salts. Unlike inorganic manganese salts (e.g. manganese sulphate), it does not cause mucosal irritation. Even with long-term supplementation of 1.0 mg of elemental manganese daily, nausea and bloating occur in only 1-2% of cases, making it suitable for individuals with sensitive stomachs, children and the elderly. Manganese gluconate has a mildly sweet taste without any metallic bitterness. It can be added directly to beverages and complementary foods (e.g. children's juices and senior nutritional porridge) without affecting the flavour of the product, which addresses the issue of poor palatability commonly associated with manganese supplements.

The aqueous solution of manganese gluconate is clear and transparent with no precipitation, making it suitable for liquid foods (e.g. sports drinks and oral liquids) and high-temperature processed foods (e.g. baked goods and sterilised milk). It demonstrates strong processing adaptability.

Mineraux®Manganese gluconate is available in the following specification and contents:

☑  Manganese gluconate anhydrous 98.0-102.0%

Due to its high absorption, low irritation and excellent palatability, Mineraux®Manganese gluconate is widely used in three major fields: food fortification, health supplements and special dietary products. It is particularly well-suited to situations that require high manganese absorption efficiency or that involve intestinal sensitivity.

In the food industry, manganese gluconate is used for nutritional fortification and flavour modification. In fortified milk powder for children and seniors, it is added in combination with calcium and vitamin D to promote bone health synergistically (manganese participates in bone matrix synthesis), making it suitable for preventing osteoporosis. In fermented milk and yoghurt, it is added after fermentation at low temperatures to avoid affecting the activity of lactic acid bacteria, enhancing the trace element balance of functional yoghurt without imparting off-flavours or affecting the taste. In beverages: Manganese gluconate fortification provides manganese with a mildly sweet taste that appeals to children and avoids the metallic taste associated with manganese sulphate. In sports drinks: It synergistically supplements zinc and magnesium. Manganese activates enzymes involved in energy metabolism (e.g. pyruvate carboxylase), thereby reducing the accumulation of post-exercise fatigue. In baked goods and flour products, manganese fortification improves biscuit crispness while maintaining stability at high baking temperatures (200°C), unlike manganese sulphate which often discolours food.

In the health supplement sector, manganese gluconate is used to provide precise manganese supplementation and achieve synergistic effects. Tablets and capsules often combine it with vitamin D and calcium for synergistic bone health, making it suitable for daily supplementation among populations deficient in manganese (e.g. vegetarians and individuals with malabsorption). Flavoured powdered/instant formulations contain stevia and citric acid and turn pale pink when dissolved (this natural colour comes from manganese ions and poses no safety risks). This format is suitable for elderly individuals or children with swallowing difficulties. Multivitamin gummies use pectin as a base and are crafted into fruit-flavoured sweets to reduce the taste of supplements and appeal to younger consumers. In bone health supplements, manganese gluconate is combined with calcium, magnesium and vitamin K, and manganese participates in collagen synthesis to enhance bone strength. This formulation is suitable for postmenopausal women and the elderly.

■ Production technology characteristics

The standard production process for Mineraux®Manganese gluconate involves neutralising gluconic acid with manganese salts. This method has a straightforward workflow and simple purity control, meeting stringent food additive standards. To avoid introducing heavy metal impurities, food-grade gluconic acid (≥98% purity) and food-grade manganese salts (typically manganese carbonate or hydroxide) are selected. The gluconic acid is heated to between 50 and 70 °C and the manganese salt is slowly added while stirring for two to four hours. The pH is then adjusted to between 5.5 and 6.5 to form a manganese gluconate solution. Add activated carbon for decolourisation for 30 minutes, then filter to remove impurities. Subsequently, use an ion-exchange resin to remove any trace heavy metals (e.g. lead or cadmium) to ensure compliance with food-grade standards. The purified solution is then concentrated to 40-50%, cooled to 10-15°C for crystallisation, separated by centrifugation and vacuum dried at 60-80 °C to obtain the final white crystalline powder product.

Manganese participates in the activation of multiple core metabolic enzymes in the human body. Manganese gluconate can optimize energy metabolism through manganese supplementation, reducing fatigue accumulation. Manganese is a component of over 30 enzymes, including pyruvate carboxylase and superoxide dismutase (SOD), participating in glycolysis, fat metabolism, and energy production. The metabolic properties of the gluconate ion accelerate manganese ion transport, rapidly activating enzyme activity.

▶ Energy metabolism

Manganese is essential for myelin synthesis and neurotransmitter metabolism. The mild properties of manganese gluconate make it an optimal choice for neuroprotection in specific populations. Manganese participates in the synthesis of sphingomyelin for myelin sheaths (the insulating layer of nerve fibers), and deficiency can lead to myelin hypoplasia. It also regulates the synthesis of neurotransmitters such as dopamine and serotonin, maintaining stable neural signal transmission.

▶ Neurodevelopment and function

Chemistry name: D-Gluconic acid, manganese(2+) salt (2:1)

CAS No.: 6485-39-8

EINECS No.: 229-350-4

Chemical formula: C12H22MnO14

Molecular mass: 445.24 g/mol

The core health benefits of Mineraux®Manganese gluconate lie in its highly absorbable organic form of manganese (35-45%, which is two to three times higher than that of inorganic manganese), as well as its minimal gastrointestinal irritation properties. Given its physiological function as an essential trace element in the human body, participating in critical processes such as bone formation, metabolic enzyme activation and neural development, manganese gluconate is particularly suitable for children, the elderly, individuals with sensitive digestive systems and pregnant women.

Physical and Chemical Properties:

Manganese is a vital component of the human antioxidant system. Manganese gluconate supplements manganese to enhance the body's ability to eliminate free radicals. As the core element of manganese superoxide dismutase (Mn-SOD), manganese converts intracellular superoxide anion radicals into harmless substances. It synergizes with vitamins C and E to form an antioxidant network, reducing damage to cell membranes caused by lipid peroxidation.

▶ Antioxidant

☑  Manganese gluconate dihydrate 98.0-102.0%

Manganese is a key factor in activating immune cells. Manganese gluconate supplements can enhance immune responses by boosting manganese levels, thereby reducing infection risks. Manganese activates the phagocytic activity of macrophages, promotes lymphocyte proliferation and antibody production, and strengthens mucosal immunity (respiratory and intestinal barriers) against pathogens.

▶ Immune health